Beyond the Flatland Library sp3 enriched

Title: Beyond the Flatland Library: Unlocking New Frontiers with sp3-Enriched Molecules


  • Introduce the concept of the “Beyond the Flatland Library” focusing on sp3-enriched molecules.
  • Highlight the limitations of traditional flat aromatic compounds and the need for three-dimensionally-rich molecules.
  • Discuss the significance of sp3-enriched molecules in drug discovery and their potential to address current therapeutic challenges.

Key Point 1: Understanding sp3-Enriched Molecules:

  • Define sp3-enriched molecules as compounds with a higher percentage of sp3 hybridized carbon atoms.
  • Discuss the structural characteristics of sp3-enriched molecules, such as increased stereochemical complexity and conformational flexibility.
  • Highlight the benefits of sp3-enriched molecules, including improved solubility, reduced toxicity, and enhanced interactions with biological targets.

Key Point 2: Advantages and Applications in Drug Discovery:

  • Present the advantages of sp3-enriched molecules in drug discovery, such as their ability to access diverse chemical space and target protein-protein interactions.
  • Discuss the applications of sp3-enriched molecules in various therapeutic areas, including oncology, CNS disorders, and infectious diseases.
  • Showcase examples of successful drug candidates derived from sp3-enriched molecules, highlighting their efficacy and selectivity.

Key Point 3: Diversity-Oriented Synthesis (DOS) of sp3-Enriched Compounds:

  • Explain the strategies and approaches used in the synthesis of sp3-enriched molecules.
  • Discuss the importance of diversity-oriented synthesis (DOS) in generating structurally diverse sp3-enriched libraries.
  • Showcase the use of fragment-based approaches, cascade reactions, and natural product-inspired synthesis in creating sp3-enriched compounds.

Key Point 4: Hit-to-Lead Optimization and Property Evaluation:

  • Highlight the challenges and strategies in hit-to-lead optimization of sp3-enriched molecules.
  • Discuss the importance of property evaluation, such as physicochemical properties, pharmacokinetics, and toxicity profiles.
  • Showcase the use of computational methods and structure-activity relationship (SAR) analysis in optimizing sp3-enriched compounds for drug-like properties.

Key Point 5: Future Perspectives and Advancements:

  • Discuss the emerging trends and advancements in sp3-enriched compound research, including the integration of artificial intelligence and machine learning.
  • Highlight the potential of sp3-enriched compounds in fragment-based drug discovery (FBDD) and chemical biology.
  • Address the need for continual exploration and collaboration to expand the field of sp3-enriched compounds and unlock new therapeutic possibilities.


  • Summarize the key points, emphasizing the growing significance of sp3-enriched compounds in drug discovery.
  • Highlight the advantages and applications of sp3-enriched molecules in addressing current therapeutic challenges.
  • Encourage researchers and scientists to explore the “Beyond the Flatland Library” to broaden the chemical space and accelerate the development of innovative and effective therapeutics.